![]() Symptoms range from mild to severe, depending upon the stage and course of the disease. Vision can be very good in bright lighting, but progressive loss of peripheral vision may eventually involve the central vision. Decreased peripheral vision (side vision) and poor vision in dim lighting are the most common early symptoms of RP. Most people begin to have problems with vision in their teenage years, but some people don’t have trouble until their 40’s. WHAT ARE THE SYMPTOMS/FINDINGS ASSOCIATED WITH RP? RP can also occur spontaneously (by a new noninherited mutation). Those defined as girls at birth have two X chromosomes while boys have only one X chromosome, leading to differences in how the different sexes are affected. Retinitis pigmentosa can also be X-linked (10-15% of cases). If the gene is recessive (5-20% of RP cases), both copies have to be defective and sometimes no one else in the family has the disease. If the problem gene is dominant (15-25% of RP cases), one abnormal copy can result in the disease and many family members are usually affected. Retinitis pigmentosa GTPase regulator (RPGR) is one of the most common genes to cause RP.Įach person usually has 2 copies of a gene. Over 100 separate genes have been identified as causes of RP. RP is usually caused by defect in a gene that is needed for photoreceptors (see above) to work well. The vision loss usually affects the peripheral vision (side vision) and dark/night vision first, but then worsens to involve the central vision as well. ![]() Retinitis pigmentosa damages the rods first and eventually the cones too. The cells that work in dim light are called rods while other cells called cones work in bright lighting and provide detailed vision. The retina contains cells that respond to light called photoreceptors. Retinitis pigmentosa (RP) is an inherited disease which causes gradual vision loss in both eyes due to damage to the retina.
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